史新元，1974年生，汉族，教授，工学博士，博士生导师，中华中医药学会会员，世界中医药学会联合会信息专业委员会委员，中医药信息研究会中医药信息数字化专业委员会委员。先后承担国家自然科学基金面上项目1项、北京市科委课题1项、北京市教委课题1项，中医局课题1项，并参与国家“973”项目、“重大新药创制”专项项目、国家“支撑计划”项目、中医药行业专项、北京市科委科技计划项目等20余项，发表学术论文百余篇，其中SCI论文20余篇，出版学术著作1部。2007年入选 “北京市科技新星”，2012年入选教育部“新世纪优秀人才支持计划”。
研究方向：
1.药用生物材料计算机模拟研究；
2.传统中药发酵的现代化技术研究；
3.中药生产过程质量控制技术研究。
近3年承担科研项目：
1.国家自然科学基金项目：基于计算机模拟的中药皂苷类成分复方配伍增溶机理研究
2.北京市科委课题：中药六神曲发酵炮制工艺的现代化研究
3.北京市教委课题：串联型中药制药过程集成建模与优化技术研究
4.北京中医药大学校自主课题：基于计算机模拟的增溶性辅料筛选方法研究
近3年发表主要论文：
1. Bing Xu, Zhaozhou Lin, Zhisheng Wu, et al. Target-oriented Overall Process Optimization (TOPO) for Reducing Variability in the Quality of Herbal Medicine Products. Chemometrics and Intelligent Laboratory Systems, 2013, 128, 144~152
2. Bing Xu, Gan Luo, Zhaozhou Lin, et al. End-point Detection of the Alcohol Adding Process in Alcohol Precipitation of Lonicerae Japonicae Based on Design Space and Process Analytical Technology. Chemical Journal of Chinese Universities, 2013, 34(10): 2284-2289
3. Zhisheng Wu, Yanfang Peng, Wei Chen, Bing Xu, Qun Ma, Xinyuan Shi, Yanjiang Qiao*. NIR spectroscopy as a process analytical technology (PAT) tool for monitoring and understanding of a hydrolysis process. Bioresource Technology, 137, 2013, 394 – 399
4. Zhisheng Wu, Qun Ma, Zhaozhou Lin, Yanfang Peng, Lu Ai, Xinyuan Shi*, Yanjiang Qiao*. A Novel Model Selection Strategy Using Total Error Concept. Talanta. 2013, 30;107: 248-254
5. Zhisheng Wu, Chenglin Sui, Bing Xu, Lu Ai, Qun Ma, Xinyuan Shi*, Yanjiang Qiao*. Multivariate detection limits of on-line NIR model for extraction process of chlorogenic acid from Lonicera japonica. Journal of Pharmaceutical and Biomedical Analysis, 2013; 77: 16-20
6. Xingxing Dai 1, Xinyuan Shi1,*, Qianqian Yin, Haiou Ding, Yanjiang Qiao *. Multiscale study on the interaction mechanism between ginsenoside biosurfactant and saikosaponin a. Journal of Colloid and Interface Science,2013,396,165~172
7. Haiou Ding1, Xinyuan Shi1,*, Xingxing Dai, Qianqian Yin and Yanjiang Qiao*. A Mesoscopic Simulation Study on the Solubilization of Menthol by Platycodin D. Journal of Engineering Science and Technology Review, 2013, 6 (2),125~129
8. Chenglin Sui, Zhaozhou Lin, Xinyuan Shi*, Yanjiang Qiao*. Validation of NIR Model for On-line Monitoring of Flos Lonicera Japonica Extraction Process with Different Batches of Materials. International Jouranal of Online Engineering,2013,4,44~48
9. Bing Xua, Zhisheng Wua, Zhaozhou Lina, Chenglin Suia, Xinyuan Shi?, Yanjiang Qiao?. NIR analysis for batch process of ethanol precipitation coupled with a new calibration model updating strategy. Analytica Chimica Acta,2012,720,22~28
10. Xingxing Dai 1, Xinyuan Shi1,*, Yuguang Wang, Yanjiang Qiao *. Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: Mesoscopic simulation. Journal of Colloid and Interface Science ,2012,384,73~80
11. Zhisheng Wu, Min Du, Bing Xu, Zhaozhou Lin, Xinyuan Shi*, Yanjiang Qiao*. Absorption characteristics and quantitative contribution of overtones and combination of NIR: Method development and validation. Journal of Molecular Structure, 1019 (2012) 97–102
12. Zhisheng Wu, Ou Tao, Xinxing Dai, Xinyuan Shi*, Yanjiang Qiao*. Monitoring blending process development of Yinhuang powder by near infrared chemical imaging. Vibrational Spectroscopy, 63(2012) 373-379
13. Zhisheng Wu, Min Du, Chenglin Sui, Xinyuan Shi*, Yanjiang Qiao*. Development and validation of PLS model using low-concentration calibration range: rapid analysis of solution from Lonicera japonica in ethanol precipitation process. Analytical Methods. 2012. 4. 1084-1088
14. Zhisheng Wu, Min Du, Chenglin Sui, Xinyuan Shi*, Yanjiang Qiao*. Validation of a NIR quantification method for the determination of chlorogenic acid in Lonicera japonica solution in ethanol precipitation process. Journal of Pharmaceutical and Biomedical Analysis. 2012, 62, 1-6
15. Zhisheng Wu, Ou Tao, Wei Cheng, Lu Yu, Xinyuan Shi*, Yanjiang Qiao*. Visualizing Excipient Composition and Homogeneity of Compound Liquorice Tablets by Near-Infrared Chemical Imaging. Spectrochimica Acta Part A. 2012, 86, 631-636
16. Zhisheng Wu, Ou Tao, Wei Cheng, Lu Yun, Xinyuan Shi*, Yanjiang Qiao*. Research on spatial distribution and composition uniformity of Rukuaixiao tablets intermediate by spectral imaging. Chinese Journal of Analytical Chemistry, 2011, 5, 628-634
17. Zhisheng Wu, Min Du, Chenglin Sui, Bing Xu, Xinyuan Shi*, Yanjiang Qiao*. Development and validation of a portable AOTF-NIR measurement method for the determination of Baicalin in Yinhuang oral solution. International Symposium on Chemistry and Pharmaceutical Science, 2012, 1322-1326
18. Zhisheng Wu, Min Du, Chenglin Sui, Zhaozhou Lin, Xinyuan Shi*, Yanjiang Qiao*. Feasibility analysis of lower limit of quantification of NIR for solvent in different hydrogen bonds environment using multivariate calibrations. International Symposium on Chemistry and Pharmaceutical Science. 2012, 296-299
通讯地址：北京市房山区良乡大学城北京中医药大学良乡校区中药学院C座4层
邮政编码：1024000
E-mail:xyshi@126.com
